| August | Time | Home | Away | Stadium | ||
| 8/14/2010 | 10:00 AM ET | Liverpool | v |
Arsenal | Emirates | |
| 8/21/2010 | 10:00 AM ET | Arsenal | v |
Blackpool | Emirates | |
| 8/28/2010 | 10:00 AM ET | Blackburn Rovers | v |
Arsenal | Ewood Park |
| September | Time | Home | Away | Stadium | ||
| 9/11/2010 | 10:00 AM ET | Arsenal | v |
Bolton Wanderers | Emirates | |
| 9/18/2010 | 10:00 AM ET | Sunderland | v |
Arsenal | Stadium of Light | |
| 8/25/2010 | 10:00 AM ET | Arsenal | v |
West Bromwich Albion | Emirates |
| October | Time | Home | Away | Stadium | ||
| 10/2/2010 | 10:00 AM ET | Chelsea | v |
Arsenal | Stamford Bridge | |
| 10/16/2010 | 10:00 AM ET | Arsenal | v |
Birmingham | Emirates | |
| 10/23/2010 | 10:00 AM ET | Manchester City | v |
Arsenal | City of Manchester | |
| 10/30/2010 | 10:00 AM ET | Arsenal | v |
West Ham United | Emirates |
| November | Time | Home | Away | Stadium | ||
| 11/6/2010 | 11:00 AM ET | Arsenal | v |
Newcastle United | Emirates | |
| 11/9/2010 | 2:45 PM ET | Wolverhampton Wanderers | v |
Arsenal | Molineux | |
| 11/13/2010 | 10:00 AM ET | Everton | v |
Arsenal | Goodison Park | |
| 11/20/2010 | 10:00 AM ET | Arsenal | v |
Tottenham Hotspur | Emirates | |
| 11/27/2010 | 10:00 AM ET | Aston Villa | v |
Arsenal | Villa Park |
| December | Time | Home | Away | Stadium | ||
| 12/4/2010 | 10:00 AM ET | Arsenal | v |
Fulham | Emirates | |
| 12/11/2010 | 10:00 AM ET | Manchester United | v |
Arsenal | Molineux | |
| 12/18/2010 | 10:00 AM ET | Arsenal | v |
Stoke City | Emirates | |
| 12/26/2010 | 10:00 AM ET | Arsenal | v |
Chelsea | Emirates | |
| 12/28/2010 | 10:00 AM ET | Wigan Athletic | v |
Arsenal | DW Stadium |
| January | Time | Home | Away | Stadium | ||
| 1/1/2011 | 10:00 AM ET | Birmingham | v |
Arsenal | St. Andrews | |
| 1/4/2011 | 2:45 PM ET | Arsenal | v |
Manchester City | Emirates | |
| 1/15/2011 | 10:00 AM ET | West Ham United | v |
Arsenal | Upton Park | |
| 1/22/2010 | 10:00 AM ET | Arsenal | v |
Wigan Athletic | Emirates |
| February | Time | Home | Away | Stadium | ||
| 2/1/2011 | 2:45 PM ET | Arsenal | v |
Everton | Emirates | |
| 2/5/2011 | 10:00 AM ET | Newcastle United | v |
Arsenal | St. James Park | |
| 2/12/2011 | 10:00 AM ET | Arsenal | v |
Wolverhampton Wanderers | Emirates | |
| 2/26/2011 | 10:00 AM ET | Tottenham Hotspur | v |
Arsenal | White Hart Lane |
| March | Time | Home | Away | Stadium | ||
| 3/5/2011 | 10:00 AM ET | Arsenal | v |
Sunderland | Emirates | |
| 3/19/2011 | 11:00 AM ET | West Bromwich Albion | v |
Arsenal | The Hawthorns |
| April | Time | Home | Away | Stadium | ||
| 4/2/2011 | 10:00 AM ET | Arsenal | v |
Blackburn Rovers | Emirates | |
| 4/9/2011 | 10:00 AM ET | Blackpool | v |
Arsenal | Bloomfield Road | |
| 4/16/2011 | 10:00 AM ET | Arsenal | v |
Liverpool | Emirates | |
| 4/23/2011 | 10:00 AM ET | Bolton Wanderers | v |
Arsenal | Reebok | |
| 4/30/2011 | 10:00 AM ET | Arsenal | v |
Manchester United | Emirates |
| May | Time | Home | Away | Stadium | ||
| 5/7/2011 | 10:00 AM ET | Stoke City | v |
Arsenal | Britannia Stadium | |
| 5/14/2011 | 10:00 AM ET | Arsenal | v |
Aston Villa | Emirates | |
| 5/22/2011 | 10:00 AM ET | Fulham | v |
Arsenal | Craven Cottage |
